Unsupported Security Settings - ActiveX

I was able to get into CRM without issue prior to this morning. I was messing with my activex controls, but now when I go to log in, I get this error (See screenshot). 

I do have the settings specified enabled, and I've tried resetting back to default/custom settings level, even restarting my computer to no avail. 

This is for CRM 2016 on-prem via the web interface.

Not sure where else to go here.