IFD and Email Server Profiles for Dev and QA environments

For others who have on-prem Dynamics and O365/Exchange Online for email (like, all 4 of us or so) - any thoughts on dealing with email setup across different Dynamics environments?  We're finally getting around to setting up a proper Dev/QA/Prod 3 server setup, and I'm not loving the idea of setting all three of them individually up for IFD, DNS aliases to be externally and internally accessible, and all of the other stuff involved in hooking them all up for O365 integration.  Plus I have no idea if the App for Outlook can work for more than one server.  But we need to be able to properly test things before Prod...  Looking for recommendations, best practices, "for the love of all that's holy don't do X", whatever thoughts people have on it.

Thanks!